Prof. Stephen Worthley graduated from Medicine at the Adelaide University, South Australia. His training included his Cardiology fellowship at the Royal Adelaide Hospital, his PhD at the Mount Sinai Medical Centre in New York, and post-doctoral research and interventional fellowship at Monash Medical Centre, Melbourne. He established the first dedicated Cardiac CT and MR units in the Asia Pacific region, as well as leading the Cardiovascular Research Centre at the University of Adelaide as the Helpman Professor of Cardiovascular Medicine, a position he held between 2004 to 2016.

He has published over 250 manuscripts, 5 book chapters, and co-edited a Cardiovascular Textbook. He leads a number of novel international multi-centre cardiovascular therapy trials, and his clinical and research expertise spans natriuretic peptide and stem cell therapies though to transcatheter valve implantation and renal artery denervation therapy. He sits on numerous industry advisory boards, journal editorial boards and government advisory groups.

In 2002 he initiated a radial artery access program at the Royal Adelaide Hospital, which rapidly evolved to become the largest volume radial access program in Australia. He is internationally renowned for his interventional and imaging academic work. He has actively trained and educated fellow Cardiologists in interventional therapies around the world, including a sabbatical in 2014 when he moved to Brussels to proctor TAVR procedures throughout Europe and North America.

In 2016 Steve became Chief Medical Officer at GenesisCare and established a national research network. Less than a year later he accepted the role of Executive Manager HeartCare and Sleepcare which saw him lead a network of over 80 Cardiologists across 6 Practices located in all mainland states of Australia. In November 2020 his remit increased to span the Integrated Cancer Care program and bring a coordinated, quality approach to the clinical care of patients with Cancer. With the completion of the North Shore Health Hub Integrated Cancer Centre, the largest single centre of it's type in Australia in August 2021, he moved on from GenesisCare to continue his focus on Cardiovascular Device innovation and clinical practice in Sydney, Australia. He has a base at Macquarie University Hospital where he holds his academic appointment and performs his clinical structural interventional work. He is also the Executive Chairman of Three Peaks Medical, a medical device company focussed on innovation in the delivery of large bore medical devices and therapies.